Iron Status in Patients with Chronic Renal Failure on Haemodialysis

Ez-Aldeen Al-Mukhtar, Safa

	Iron Status in Patients with Chronic Renal Failure on Haemodialysis
Iraqi Postgraduate Medical Journal
Article 1, Volume 5, Issue 3, 2006, Pages 318-324 PDF (0 K)
Author
Safa Ez-Aldeen Al-Mukhtar
Abstract
ABSTRACT: BACKGROUND: Anaemia is common in renal failure. Serum iron (SI), and the percentage of transferrin saturation (TSAT) reflect the amount of iron immediately available for haemoglobin (Hb) synthesis. Serum ferritin level reflects total body iron stores. Adequate iron stores are essential for achieving maximum benefit from recombinant human erythropoietin (Epo). A low level of either of these indices may indicate the need for supplement iron to support erythropoiesis. METHODS: Seventy Patients with end stage renal disease (ESRD) on regular haemodialysis (HD) were included in this study from three dialysis centers in Baghdad: We have collected data on, serum iron, total iron binding capacity (TIBC), TSAT, Serum ferritin, and blood film, was done. Fifty subjects were included in the control group. RESULTS: A44 patients (62.9%) were receiving regular parenteral Iron Dextran with Epo, and 26 patients (37.1%) were receiving irregular oral or intramuscular iron Dextran with Epo. According to the serum ferritin, 41 patients (58.6%) involved have serum ferritin level >300ng/ml, of them; the TSAT was > 20% in 27 patients while TSAT ≤ 20% in 14 patients in this group, and Hb was > 11 g/dl in 11 patients where as ≤ 11 g/dl in 30 patients in this group. Serum ferritin in 29 patients (41.4%) was ≤ 300 ng/ml, of them, the TSAT was ≤ 20% in 26 patients and > 20% in three patients only, the Hb level was ≤ 11 g/dl in all patients in this group. There was significant correlation with anaemia. (Hb ≤ 11 g/dl) and low serum ferritin (P<0.005), patients with TSAT ≤ 20%, all were anaemic (Hb≤11 g/dl) and there was a significant association between these two markers (P<0.005). In patients receiving regular parenteral iron and Epo (44 patients) (62.9%), the TSAT was > 20% in 21 patients (30%), while those who taking no or irregular iron therapy with Epo (26 patients) (37.1%), the STAT was >20% in 9 (12.9%) the difference was not statically significant. CONCLUSION: The serum ferritin in our study group was higher than that reported in other studies. Serum ferritin of ≤ 300 ng/ml, and TSAT of≤ 20% in our study group was significantly correlated with anaemia. Serum ferritin of ≤ 300 ng/ml and a TSAT of≤ 20% were significantly associated.
Keywords
Iron Deficiency; Anaemia; Serum ferritin; Haemodialysis; Renal failure

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