The Role of Garlic Extract on the Effect of Organic Pesticides on Murine Liver Cells

Hamdan Gathwn, Khalid

	The Role of Garlic Extract on the Effect of Organic Pesticides on Murine Liver Cells
Iraqi Postgraduate Medical Journal
Article 1, Volume 5, Issue 3, 2006, Pages 344-350 PDF (0 K)
Author
Khalid Hamdan Gathwn
Abstract
ABSTRACT: BACK GROUND: Organic phosphorus pesticides are most widely preferred pesticides, and know to have detrimental effect on various living organisms. METHODS: Twenty four male Balb/c mice were used. These were divided into four group (1,2,3,4) . Chlorpyriphos was given orally on alternate days by garage (20mg/kg body weight), aqueous garlic alone was given orally daily by garage (200mg/kg body weight, while garlic extract followed by chlorphriphos was also given. RESULTS: Lipid peroxidation (LPO) was measured in liver homogenate . The extent of LPO was significantly increased in animals treated with pesticide while non-significant result were obtained with garlic extract alone . Pretreatment with garlic followed by pesticide showed similar values. The levels of glutathione and total thiol was significantly decreased in animals treated with pesticide and non- significant with garlic . pretreatment with garlic followed by pesticide showed similar value. The free radical scavenging enzyme like SOD , as well as GSH- dependent enzyme (GPx, GST and GR) show significant decrease in animals treated with pesticide and non-significant with garlic. Pretreatment with garlic followed by pesticide showed similar to that of control. CONCLUSION: Pesticide exposure could be prevented by Co-administration of garlic extract.
Keywords
Chlorpyriphos; Garlic extract; LPO; Glutathione

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