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Synthesis and Characterization Of Some New Heterocyclic Compounds Such As: Oxadiazole and Azetidine-2-One Derivatives | ||
| Iraqi National Journal Of Chemistry | ||
| Article 1, Volume 0, Issue 44, 2014, Pages 571-581 | ||
| Author | ||
| Mahmood Shakir Magtoof AL-Tamemay | ||
| Abstract | ||
| Abstract A series of four membered ring the azetidine-2-one 3(a-c) have been synthesized via Schiff bases 2(a-e) with derivative of acetic acid in the presence of triethylamine with phosphorusoxychloride using dry methylene chloride under inert nitrogen atmosphere at 0 ˚C. to furnish the corresponding azetidine-2-one 3(a-c) in moderate yields.on the other hand aseries of five membered ring synthesized Substituted 1,3,4-oxadiazoles are of considerable pharmaceutical and material interest by treatment of a suspension of methyl salicyliate hydrazide (1) in ethanol reflux with hydrazine to give 2-hydroxybenzohydrazide (2) this compound treated with Carbon disulfide(CS2) in the presence of sodium hydroxide to give 2-mercapto-1,3,4,-Oxadiazole (3)this compound treated with hydrazine in ethanol to give 5-hydrazino-1,3,4-Oxadiazole(4). Finally treatment of (4) with 2-bromobenzaldehyde to gave 1,3,4—Oxadiazole derivateives The structural of these compounds were monitored and confirmed by using spectroscopic tools as IR and 1HNMR spectra Elemental analysis. | ||
| Keywords | ||
| medicinal chemistry; lactam; ketene; Staudinger reaction; four membered ring; oxadiazole | ||
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