A. Ahmed, B., J. Mohammed, S. (2011). Synthesis of some new substituted (α٫α-diphenyl-α-hydroxymethyl) -1,3,4-oxadiazoles as possible biological active compounds. , 0(44), 582-589.
Badie A. Ahmed; Salem J. Mohammed. "Synthesis of some new substituted (α٫α-diphenyl-α-hydroxymethyl) -1,3,4-oxadiazoles as possible biological active compounds". , 0, 44, 2011, 582-589.
A. Ahmed, B., J. Mohammed, S. (2011). 'Synthesis of some new substituted (α٫α-diphenyl-α-hydroxymethyl) -1,3,4-oxadiazoles as possible biological active compounds', , 0(44), pp. 582-589.
A. Ahmed, B., J. Mohammed, S. Synthesis of some new substituted (α٫α-diphenyl-α-hydroxymethyl) -1,3,4-oxadiazoles as possible biological active compounds. , 2011; 0(44): 582-589.

Synthesis of some new substituted (α٫α-diphenyl-α-hydroxymethyl) -1,3,4-oxadiazoles as possible biological active compounds

Iraqi National Journal Of Chemistry
Article 1, Volume 0, Issue 44, 2014, Pages 582-589
Authors
Badie A. Ahmed; Salem J. Mohammed
Abstract
Abstract
The reaction of benzilic acid hydrazide (1) with carbon disulfide
in the presence of potassium hydroxide yielded 5-(α٫α-diphenyl –α-hydroxymethyl )-1,3,4-oxadiazoline -2-thione (2) ,this product was subjected to the following reactions :Alkylation with methyl iodide and potassium hydroxide to give 5-( α٫α-diphenyl –α- hydroxymethyl )-2-thiomethyl-1,3,4-oxadiazole (3).Reaction with substituted aldehyde was carried out to give 5- (α٫α-diphenyl –α-hydroxymethyl )-3-(α-aryl-α-hydroxymethyl)-1,3,4-oxadiazoline -2-thione ( 4a-f). Finally reaction with different amines was performed to afford 5- (α٫α-diphenyl –α-hydroxymethyl ) -3-(substituted amino methyl)-1,3,4-oxadiazoline -2-thione(5a-f) by the Mannich reaction . The structures of all compounds were confirmed by physical and spectral methods.
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