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Histopathological study on liver of mice infected with Cryptosporidium parvum and treatment with Azithromycin, Spiramycin alone and mixed with vitamin E | ||
| Al-Anbar Journal of Veterinary Sciences | ||
| Article 1, Volume 3, Issue 2, 2010, Pages 63-75 PDF (351.73 K) | ||
| Authors | ||
| S. A. A. Al-Jarjary; E. R. Al-Kennany; O. A. N. Abbu | ||
| Abstract | ||
| This study was conducted to induce infection with Cryptosporidiosis experimentally in white mice through inoculation with Cryptosporidium parvum then treatment with azithromycin and spiramycin alone or mixed with vitamin E as antioxidant in order to know the histopathological changes of liver and to compare with mice liver not infected and not treated. The results showed the presence of histopathological changes on liver of mice infected with Cryptosporidium parvum represented by vacuolar degeneration and hypertrophy of kupffer cells, localization of parasite in cytoplasm of hepatocyte and presence of parasitiphorous in group treated with spiramycin and azithromycin alone showed regression and shrunkage of parasite associated with presence of mild vacuolar degeneration while in group treated with vitamin E , the results showed regression and disappearance of parasite in some sections through 14-30 days of treatment. In the study concluded that spiramycin and azithromycin have a high effect on the parasite when mixed with vitamin E. | ||
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