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PHYSICO-CHEMICAL AND ENZYMATIC STUDY IN TYPE1 DIABETES MELLITUS | ||
| AL-TAQANI | ||
| Article 1, Volume 22, Issue 2, 2009, Pages 17-26 | ||
| Authors | ||
| Dhammyaa H. Salih; ; Sanad B. AL-A; Ali M. AL-Gharawi; Khalid I. Husain | ||
| Abstract | ||
| This study included 130 Type 1 diabetic patients who were admitted to the Center of Endocrinology and Diabetes near AL-Kindy Teaching Hospital ; from Nov. 2006 to April 2007, in addition to 40 apparently healthy subjects used as control. Fasting blood glucose (FBG) , C-Peptide, HbA1c , Lipid profile and body mass index (BMI) were performed for all.. This study revealed that the disease is prevalent among male ( 58.5%) , majority of them ( 55.4% ) at age of ( 11-17) years with highly significant difference in comparison with other age groups ( P<0.001) . It was clear that the genetic factor has a crucial role in susceptibility for the disease with previous family history ( 87.7% ) (P<0.001). The majority of diabetic patients (43.8%) had a disease duration range (1-5 years). Most of patients ( 79.8%) were students (P,0.001). The mean of FBG among diabetic patients was highly significantly elevated (13.58±3.39 m mole / L ) in comparison with healthy individuals ( 4.427± 0.72 m mole/L ) ( P=0.001 ) .HbA1c mean has been increased significantly among diabetic ( 11.62% ± 2.86) in comparison with control group ( 4.66% ± 0.72 ) ( P =0.001). No significant variation was noticed between BMI value of diabetic patients type 1 (17.44 Kg/m² ± 2.83), in comparison with control group ( 16.72 Kg/ m² ±3.40) (P=0.184). Lipid profile determination showed that there was significant elevation in serum cholesterol of DM type 1 ( 4.626 ± 1.272 m mole / L ) and triglycerides ( 1.441 ± 0.741 m mole/ L ) in comparison with healthy controls ( 3.975 ± 0.994 & 0.970 ± 0.389 ) . There was a strong correlation between disease duration and most of the above parameters such as C-peptide , FBG , LDL, HDL and triglyceride , while the latter was associated with BMI ( P = 0.011). | ||
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