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Antibacterial activity of Thymus vulgaris and Prunus amygdalus extracts against bacterial wound infection | ||
| Al-Mustansiriyah Journal for Pharmaceutical Sciences | ||
| Article 1, Volume 10, Issue 2, 2011, Pages 198-205 | ||
| Authors | ||
| Fitua M.Aziz; Suhad F.Hatem; Mohammed Kadum Al-Araji | ||
| Abstract | ||
| Eighty clinical swabs were collected from Patients suffering from wound infection, attending medical city hospital Sixty seven isolates were diagnosed as causative agents, they were Klebsiella spp. (22.4 %), Escherichia coli (22.4%), Pseudomonas spp. (18%), Staphylolcoccus aureus(15%),Enterobacter spp(10.4%), Proteus spp (7.5%) Streptococcus spp (3%) and Acinetobacter spp.(1.5%); Eleven antibiotics were used for suscpitbility test of drugs. Most of isolates were sensitive to lmipenem in percentage 97% and Amikacin in percentage of 89.5% while most isolate were resistance for many antibiotics like Cefotaxim (89.5%), Tetracyclin (82%), Tobramycin (77.6%), Pipracilin (77.6%) and Gentamycin (77.6%), isolates from gram positive bacteria showed sensitivity (100%) for Vancomycin . Antimicrobial activity of Thymus vulgaris and prunus amygdalus against higher resistance isolates was estimated, using two folds dilution extracts in agar diffusion technique at concentrations of 1:2, 1:4 , 1:8, 1:16, 1:32 .Thymus vulgaris has shown anti bacterial activity against Acinetobacter spp., proteus spp. And Klebsiella spp.in all concentration were used .The lowest effect was on E.coli (12 mm, 8 mm) at concentration 1:2, 1:4. No effect was clear on Pseudomonas spp., Staphylococus aureus and Streptococcus spp . Hexane extract of Sweet almond extract showed the best effect on Klebsiella spp.,Enterobacter spp., Proteus spp. at all concentrations used, while E.coli and pseudomonas spp showed sensitivity concentrations of 1:2, 1:4, 1:8, the activity on Gram positive bacteria :Staphylococus aureus and Straptococus spp. was at concentrations of 1:2 , 1:4 by measuring inhibition zone which was (8mm,7mm) and (10mm,9mm) respectively. | ||
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