Study the effects of Cadmium chloride on some cytogenetic parameters in albino rat

Jafar Abd-Ali, Dhafera; S. Z. Al-Shebli, Karrar

	Study the effects of Cadmium chloride on some cytogenetic parameters in albino rat
Kufa Journal For Veterinary Medical Sciences
Article 1, Volume 1, Issue 1, 2010, Pages 67-84
Authors
Dhafera Jafar Abd-Ali; Karrar S. Z. Al-Shebli
Abstract
Abstract: The current study was carried out in the animal house of the College of Medicine in University of Kufa. It was conducted also in the laboratories of histopathology and biochemistry in Al-sadir Educational Hospital and Higher Education laboratory in the College of Education for girls / Kufa University, during the period 25/10/2008 – 19/3/2009. It was designed to demonstrate the influence of acute dose of Cadmium Chloride (75mg/kg) and oral subchronic administration (10,20,30) mg CdCl2/L with drinking water for the periods (3,6,9) weeks in some cytogenetic parameter which include Argyrophilic Nucleolar Organizing Region (AgNOR) in duodenum, liver and kidney and the Micronuclei (MN) in Polychromatic Erythrocytes (PCE) of bone marrow. It is found that the effect of acute and subchronic administration in some of the cytogenetic parameters has reveal significant elevation in the mean of AgNOR of kidney and MN in PCE exposure to CdCl2 in acute administration compared with the control group, while in subchronic administration the significant increase happened in AgNOR of kidney and liver tissues at the concentration 30 mg CdCl2/L and period 9 weeks, in addition to significant elevation of MN which was affected by the elevation of dosing level (20,30) mg CdCl2/L from drinking water, prolonged of duration ( 9 weeks ) and the interaction between these two factors.

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