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Studies of the antiviral activity of the Dichloraflavon against Polio virus and Rubella Virus in tissue culture | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 15, Issue 3, 2010, Pages 11-14 | ||
| Authors | ||
| Abdul latif Mohamed Ahmad; Mohamed Omar Abdul latif | ||
| Abstract | ||
| Flavone originally founded in herbs and plants such as beans, tomato and grapefruit. Dichloraflavan relatively non-toxic, we find in this study that when we test the toxicity of this compound in the following tissue culture (HeLa, WISH, RD and L20B) and we find also that the toxic concentration between 16-32 µg/ml. The concentration 0.06 µg/ml inhibit (100TCID50) of poliovirus in RD cells and L20B cells. used the Therapeutic Index (TI) which is the ratio between the toxic concentrations of the drug over the minimal inhibitory concentration. If the TI one or less means that the compound not advise to use due to the high side effect while if the TI more than one compound maybe used for treatment. The TI of the compound against Polio virus more than 100 This means that the compound in case of used as treatment in human has no any side effect. | ||
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