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Heterocyclic Synthesis Via Phosphine imino Intermediate | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 15, Issue 3, 2010, Pages 48-55 | ||
| Author | ||
| Harith M. Al-Ajely | ||
| Abstract | ||
| In this work heterocyclic compounds were prepared by two path ways. The first one includes the preparation of 2-nitro, 2,4-dinitroazido benzene (1a,b) from the reaction of 2-chloro, 2,4-dinitrochloro benzene with sodium azide which are further reacted with triphenyl phosphene resulted into the formation of phosphene imine (2a,b), these compounds were allowed to react with some isocyanate compounds to afford compounds (3-6). The second path includes the synthesis of ethyl azidoacetate and ethyl 2-propionate (7a,b) from the reaction of ethyl bromoacetate, ethyl 2-bromopropionate with sodium azide, these compounds were allowed to react with triphenyl phosphene forming phosphoimine compounds (9a,b), these compounds were reacted with butyl isocyanate resulted into the formation of carbodiimide compounds (10a,b), which were cyclized by their reaction with some primary amines and amino acid esters. All synthesized compounds were identified by melting point and I.R spectroscopy and their results were discussed. | ||
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