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EFFECT OF ANTIANDROGEN (FLUTAMIDE) ON LEVELS OF SOME LIVER ENZYMES IN ALBINO MALE RATS | ||
| AL-TAQANI | ||
| Article 1, Volume 22, Issue 4, 2009, Pages 0-0 | ||
| Abstract | ||
| This study was performed to determine the effects of antiandrogen flutamide on values of some liver enzymes GOT,GPT,ALP of male rats during prepuberty- puberty at age 30-60 days. The treatment of first group male with s.c. 10 mg/kg/day flutamide caused significant increase (P<0.01) in values of liver enzymes GPT, GOT compared with second (control) group. The values of ALP were not affected significantly (P>0.05) .The values of the three enzymes in the orally treated group(third) showed no significant differences (P>0.05)when compared with fourth group (control). After treatment with flutamide(10 mg / kg/ day), results revealed significant increase(P<0.01) in values of GPT and GOT of the first group (s.c.) in comparison with these of third group(oral) . ALP levels ,however, showed no significant differences(P>0.05). Changes in enzyme levels may be attributed to the fact that the liver being responsible for metabolism of most drugs influencing morphology and function of hepatic cells . | ||
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