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The Role of Anticardiolipin and Anti-B2 Glycoprotein Antibodies in Clinical Complication of Lupus Nephritis | ||
| Iraqi Postgraduate Medical Journal | ||
| Article 1, Volume 7, Issue 1, 2008, Pages 22-25 PDF (0 K) | ||
| Author | ||
| Nawar Abass Abud Noor | ||
| Abstract | ||
| ABSTRACT: BACKGROUND: Although there was confliction regarding the association of raised anticardiolipin antibodies (ACL) level with renal disease in systemic lupus erythematosus (SLE), the role of B2glycoprotein as a cofactor for ACL binding is established.The presence of ACL &anti-B2GPІ may be directly involved in pathogenesis of antiphospholipid antibodies associated symptoms like recurrent fetal loss, thrombocytopenia and thrombosis. AIM OF STUDY: To study the possible association between some auto antibodies with the most common clinical complication of disease. PATIENTS AND METHODS: The study was conducted on 25 patients with lupus nephritis, attended the renal clinic in specialized surgical hospital/ medical city /Baghdad, 25 lupus patients without nephritis and 25 healthy controls. Enzyme linked immunsorbant assay was used for detection for ACL, anti-B2GP. RESULT: Although there was no significant difference in mean concentrations of ACL and anti- B2GP between lupus nephritis and without nephritis (P>0.05), lupus nephritis patients were more likely positive for ACL. Positivity of 100% For ACL & anti- B2GPwere detected in thrombotic complication, in fetal loss complication patients more likely to be positive for ACL (75%), anti- B2GP (50%), in thrombocytopenia positivity of ACL &anti-B2GP (75%). CONCLUSION: There was no association between anti-B2GP and renal disease and presence of both ACL &anti- B2GP carry higher risk for thrombosis and recurrent fetal loss. | ||
| Keywords | ||
| Anticardiolipin antibodies; anti; glycoprotein antibodies; lupus nephritis | ||
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