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Cytotoxic effect of Azurin Produced from Pseudomonas aeruginosa Ps21 on cancer cell lines (Hep-2 and AMN-3) | ||
| Iraqi Journal of Cancer and Medical Genetics | ||
| Article 1, Volume 3, Issue 2, 2010, Pages 59-64 | ||
| Authors | ||
| Aiman A.Hassan; Amal M.Ali; Hayfa H.Hassani; Nihad T.Mohamed | ||
| Abstract | ||
| This stady was amied to detection the ability of azurin , produced from Pseudomonas aeruginosa Ps21, as inhibitor two types of cancer cell lines, human laryux epidermoid carcinoma ( Hep – 2 ) and Mouse Mammary adenocarcinoma (AMN – 3 ) by using cytotoxicity assay. The Results showed the effect of partial purified of azurin depended on the concentration , type of cell and the exposure time. The extract at high concentrations ( 125 , 250 ) μg/ml. were exhibited apotent inhibiory at all exposure time against cancer cell lines. While The inhibitory activity was gradually reduced with decreasing of concentration of azurin , the low concentrations were activated for the cells proliferation in comparison with the control (100 %). The viability of Hep – 2 cells was increased only during the first 24 hr from exposure while the AMN – 3 cells were proliferated at all exposture times (24 , 48 , 72) hr. | ||
| Keywords | ||
| Pseudomonas aeruginosa | ||
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