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AGE-RELATED CHANGES IN THE LIPID PEROXIDATION AND ANTIOXIDANT SYSTEMS OF MALE SUBJECTS | ||
| AL-TAQANI | ||
| Article 1, Volume 22, Issue 4, 2009, Pages 112-117 | ||
| Authors | ||
| Saad Abid Al-rahmman Hussien; Hameed Mahmood Majeed; Layth Abid Al- Kareem | ||
| Abstract | ||
| The effect of aging on the lipid peroxidation and antioxidant systems was evaluated in this study. For this purpose, we determined MDA as a marker of lipid peroxidation in blood serum, haemoglobin in whole blood, reduced glutathione (GSH) , total protein, albumin, and uric acid in blood serum as well as catalase and glutathione-s-transferase in serum of 84male healthy individuals (non-smokers). These subjects were divided in to three groups: group1 (n=28;25-34years old); group2(n=28;35-44 years old); group3(n=28;45-63 years old). The result showed increased levels of MDA and were observed as the stage of age increased P>.05). Whereas there is a depletion in GSH levels related to age increase (P < 0.05), which indicate that the low levels of GSH in the circulation may be due to their increased utilization to scavenge lipid peroxide. There was higher levels of catalase and GST in group3 compared with others.Group2 showed lower level in haemoglobin and higher level in albumin compared with other groups(P < 0.05).No meaningful differences were found in terms of serum total protein and uric acid levels. | ||
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