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Nephro-Protective Effect of Punica granatum in Gentamicin-Induced Nephrotoxicity in Rats | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 9, Issue 1, 2012, Pages 220-228 | ||
| Authors | ||
| Nidhal AK Mohammed Ali; Shatha Z Saeed | ||
| Abstract | ||
| The aqueous extract of Punica granatum (AEPF) was investigated for its protective effects on gentamicin-induced renal toxicity in rats. Nephrotoxicity was induced by intraperitoneal injection of gentamicin (100 mg/kg) for 8 days. The effect of AEPF (100mg/kg) given orally either with gentamicin or after 8 days of gentamicin administration was assessed by biochemical and histopathological changes of kidneys. AEPF protected the rats from alteration in serum levels of urea, creatinine, uric acid, sodium, potassium and chloride better when co-administered with gentamicin than when given after induced gentamicin nephrotoxicity and also through reversing the mild tubular necrosis than severe tubular necrosis. | ||
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