A Study on the Relationship between Thyroid Hormones and Adenosine Deaminase Enzyme Activity in Patients with Auto- Immune Hyperthyroid Disease

Khlil Abbas, Ahsan

	A Study on the Relationship between Thyroid Hormones and Adenosine Deaminase Enzyme Activity in Patients with Auto- Immune Hyperthyroid Disease
Iraqi Postgraduate Medical Journal
Article 1, Volume 7, Issue 2, 2008, Pages 164-167 PDF (0 K)
Author
Ahsan Khlil Abbas
Abstract
ABSTRACT : BACKGROUND : Adenosine deaminase ADA catalyzes the deamination of adenosine in purine metabolism . Adenosine deaminase deficiency is an inborn error resulting in immunodeficiency condition . clinical interest in this enzyme has been revived by the discovery of a syndrome of severe humoral and cellular immunodeficiency associated with deficiency of ADA in somatic erythrocyte cell . AIM OF STUDY: The aim of present study is conducted to find the relationship between human hyperthyroid activities and immune etiology in graves disease. MATERIALS AND METHODS : Forty individuals with hyperthyroidism autoimmune state were included in this study in comparison with forty normal persons . Thyroid hormones levels were estimated by HPLC and serum ADA specific activity was estimated using spctrophotometric method at 265 nm . Serum protein value was determined by Bradford method . RESULTS : Serum ADA activity was measured for 40 hyperthyroid patients as well as 40 normal individuals . The mean activity of ADA in patients was higher than in the controls . A significant increase in T3 / T4 ratio and level of TSH were noticed . CONCLUSION : A positive correlation between thyroid level and ADA enzyme activity was noticed .
Keywords
grave; hyperthyroid activity adenosine deaminase

Statistics Article View: 307 PDF Download: 147