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STUDY THE EFFECT OF SELECTIVE ORGANIC COMPOUNDS ON THE ACTIVITY OF ALANINE AMINO TRANSFERASE [ALT] IN SERA OF NORMAL AND PATIENTS WITH LIVER DISEASES | ||
| AL-TAQANI | ||
| Article 1, Volume 22, Issue 4, 2009, Pages 118-129 | ||
| Author | ||
| Wesen Adel Mehdi | ||
| Abstract | ||
| Human serum ALT activity was measured in vitro in sera for 40 normal persons, their age ranged between [10-25] years which showed a wide activity range between (6-14) U/L. The ALT activity in patients with different liver diseases, total serum bilirubin ranged between [1.5-7.0]mg/dl which showed the ALT activity range between [28-88]U/L. Different organic compounds were examined regarding their effects on the activity of ALT in sera from normal and patients with liver diseases. ALT activity was inhibited by four of these compounds, and the other compounds affected as activators, one of them was chosen to reactivate the activity of inhibited ALT. The inhibitory effect of two different concentrations of the four compounds were studied , using five different concentrations of the substrate. The percentage type of inhibition and the recovery percentage were calculated with the absence and with the presence of different concentrations of these compounds. | ||
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