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HPLC WITH UV DETECTION OF PSEUDOURIDINE AS TUMOR MARKER FOR BREAST TUMOR IN VIVO | ||
| AL-TAQANI | ||
| Article 1, Volume 22, Issue 4, 2009, Pages 145-151 | ||
| Authors | ||
| Amal Rasheed Ferhan; Rajha Al- Naiemi; Saosun Abd Al-Shaheed | ||
| Abstract | ||
| This work was done to evaluate the role pseudouridine status which is modified nucleoside in the serum of breast tumor patients. Serum Pseudouridine was measured by HPLC ( high performance liquid chromatography with UV detection), and to study its effect on serum of 12 normal healthy volunteers compared to values obtained from 30 subjects with breast tumor groups (malignant and benign) , all subjects aged between (30-60) years as compared with control. The statistical analysis for the data obtained in the present study showed that the concentration level of pseudouridrine was significantly elevated in the patients with malignant tumors as compared with controls but serum showed slightly increased but not significant in benign breast tumor patients as compared with controls. The result observed shows that the concentration levels of this type of modified nucleosides could be a useful parameter for the early diagnosis of patients with breast tumor , so this method suggested that this compound is a sensitive marker for breast tumor patients. | ||
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