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Detection of extended spectrum B-lactamase in E. coli from clinical samples | ||
| Annals of the College of Medicine, Mosul | ||
| Article 1, Volume 37, Issue 1, 2011, Pages 122-128 PDF (0 K) | ||
| DOI: 10.33899/mmed.2011.35783 | ||
| Author | ||
| Ansam M. Hamdoon | ||
| Abstract | ||
| Objectives: 1- To study the frequency of ESBL (extended spectrum beta lactamase) among E. coli clinical isolates. 2- To determine the antibiotic profile for the isolates. 3- To determine the difference between the antimicrobial susceptibility of the ESBL producing E. coli and non producers. Methods: A 4-months review of patients from three different hospitals who were diagnosed to have genitourinary tract infections with E. coli. These isolates were identified and assessed for their production of B-lactamase, and their antibiotic susceptibility to 21 different antimicrobial agents was determined. Results: Out of the total 136 E. coli isolates, 58.82% were found to be ESBL producers. The most effective antimicrobial agent against the isolates was amikacin (85%), followed by ciprofloxacin (67.6%), while all the isolates were fully resistant to penicillin, cephradine, cephalothin and carbencillin. Multi-drug resistance (MDR) were found to be more among the ESBL producers. There was a statistical association between the production of B-lactamase and the resistance to Amikacin, nitrofurantoin, levofloxacin, kanamicin, nalidixic acid, gentamicin, piperacillin, cefotaxime and cephalexin. Conclusions: This study shows that E. coli recovered from clinical specimens produce B-lactamase in high percentage and are resistant to penicillins and most cephalosporins. In addition, the MDR was higher among the B-lactamase producers. Therefore, determination of B-lactamases production, antimicrobial sensitivity of the isolates and strict antibiotic policy should be adopted in hospitals to take steps for reducing the bacterial resistance. | ||
| Keywords | ||
| lactamase; coli | ||
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