Voltammetric  Determination of  Dexamethsone in Serum, Urine and Drugs

M. Daowd, Suhair; M. AL- Healy, Fanar; T. Sulaiman, Sadallah

doi:10.33899/rjs.2010.36046

	Voltammetric Determination of Dexamethsone in Serum, Urine and Drugs
Rafidain Journal of Science
Article 8, Volume 21, Issue 7, 2010, Pages 106-122 PDF (0 K)
DOI: 10.33899/rjs.2010.36046
Authors
Suhair M. Daowd; Fanar M. AL- Healy; Sadallah T. Sulaiman
Abstract
The present work involves a study of the polarographic behaviour of pure Dexamethasone by direct method in aqueous solution , which shows a well defined reduction peaks at a potential (-1.08) V. in phosphate buffer (pH=7) and (-0.84) V. in phosphate buffer (pH=3). The calibration of Dexamethasone was constructed in phosphate buffer (pH=3and7) for the range of concentration (2.4910-6M)-(1.5410-5M)in phosphate buffer (pH=7) with a correlation coefficient (0.9949), and with a range of concentration (6.310-7M)-(1.5410-5M) in phosphate buffer (pH=3) with a correlation coefficient (0.9957). The calibration curve of Dexamethasone in presence at human blood serum in the range of concentration (3.1110-6M)-(9.2810-6M) in phosphate buffer (pH=7) with a correlation coefficient (0.9892), and range of concentration (6.210-7M)-(6.2110-6M) in phosphate buffer (pH=3) with a correlation coefficient (0.9873). The calibration curve of Dexamethasone in presence of urine in the range of concentration (1.8610-6M)-(1.5310-5M) in phosphate buffer (pH=7) with a correlation coefficient (0.9813), and with a range of concentration (6.210-7M)-(1.2310-5M) in phosphate buffer (pH=3) with a correlation coefficient (0.9974). The method was successfully applied to the determination of Dexamethasone in tablets and syrup in aqueous solution.

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