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Synthesis and characterization of heterocyclic compound derivatives from 2-azo benzothiazole have possible biological activity | ||
| karbala journal of pharmaceutical sciences | ||
| Article 8, Volume 2, Issue 2, 2011, Pages 81-96 PDF (0 K) | ||
| Authors | ||
| ; Entesar.O. AL-tememi | ||
| Abstract | ||
| Reaction of different substi tuents of 2-azobenzothiazolyl 4-phenols (I) with ethyl 2-bromo propionate to produce the derivatives (II) that react with thiosemicarbazide gave N-substituted thiosemicarbazide (III) also react with semicarbazide and which gave N-substituted semicarbazide (IV). The 1,2,4-triazole derivatives (V) and 1,3,4- thiadiazole derivatives (VI) were prepared by the cyclization of N-substituted thiosemicarbazide (III) with base and with concentrated sulphuric acid respectively . The 1,3,4-oxadiazole derivatives (VII) were prepared by the cyclization of N-substituted semicarbazide (IV) with acid. the new compounds were established on the basis of IR, 1H NMR and UV spectral data. | ||
| Keywords | ||
| synthesis; azobenzothiazole; biological activity | ||
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