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Synthesis of new heterocyclic rings including four,five and seven member rings with study their biological activity | ||
| karbala journal of pharmaceutical sciences | ||
| Article 13, Volume 2, Issue 2, 2011, Pages 134-156 PDF (0 K) | ||
| Authors | ||
| Ismaeel Y.Majeed; Mohanned J.Mahmoud; Ibtisam K.Jassim | ||
| Abstract | ||
| A new series of heterocyclic compounds including four, five and seven member rings have been synthesized. These compounds including N,N'-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(substituted) [1,2], ,4(1,4 phenylene)bis(3-chloro-1-(alkyl)azetidine -2-one(3,4) , 1,4-bis(1-(substituted)-2,5-dihydro-1H-tetrazole-5-yl)benzene (5,6), 2,2-(1,4-phenylene)bis(3-(alkyl)-2H benzo[1,3]thiazine-4(3H-one)(7,8). 2,2-(1,4-phenylene)bis(3-(alkyl)-2,3-dihydroquinazoline-4(1H)one)(9,10). thiazepine derivatives(11,12). (5z,5z)-2,2-(1,4-phenylene)-2,3dihydro-1,3-oxazepine-4,7-dione (13,14) and 3,3-(1,4-phenylene)bis(4-(alkyl)-3,4-dihydrobenzo[1,3]oxazepine-1,5-dione(15,16,17,18) . The structures of these compounds characterized by (FT-IR, H-NMR) spectroscopy and C.H.N analysis ,melting points and checked through T.L.C. The biological activity of these compounds was tested against Staph. Aureus, E. coli , Sal. typhi and Ps. Aerugenosa bacteria. | ||
| Keywords | ||
| Heterocyclic; oxazepines; Azetidine; tetrazoles | ||
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