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Synthesis and characterization of some substituted heterocyclic compounds and evaluation of biological activity | ||
| karbala journal of pharmaceutical sciences | ||
| Article 20, Volume 2, Issue 2, 2011, Pages 228-240 PDF (0 K) | ||
| Authors | ||
| Wissam K.Jassim; Amina A. Fayad; Ibtisam K.Jassim | ||
| Abstract | ||
| This work includes preparing of some new derivatives of 1,2,4-Triazoles and oxazoles from the reaction between 3,5-dimethyl phenol and chloroethyl acetate in the presence of potassium carbonate and dry acetone to obtain the ester ethyl 3,5-dimethyl phenoxy acetate , then converted this ester to Thiosemicarbazone and Semicarbazone. Then ,the Triazoles were prepared from the cyclization of these Thiosemcarbazones and Semicarbazones in alkaline media( potassium hydroxide solution) . The prepared compounds were characterized by spectral methods FT-IR ,1H-NMR and measurement of some of its physical properties and evaluation of the biological activity for some of them. | ||
| Keywords | ||
| Triazole; oxazole; biological activity | ||
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