Preparation and characterization of some new heterocyclic compounds with evaluating of its biological activity

K. Jassim, Wissam

	Preparation and characterization of some new heterocyclic compounds with evaluating of its biological activity
karbala journal of pharmaceutical sciences
Article 21, Volume 2, Issue 2, 2011, Pages 241-256 PDF (0 K)
Author
Wissam K. Jassim
Abstract
A series of compounds of p-Nitro ethyl benzoate [2],p-Nitro benzoic hydrazide [3], 1-phenyl-4-(p-nitrophenyl) thiosemicarbazide [4], 3-mercapto-4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole[5], 3-hydrazino -4-phenyl-5- (p-nitro phenyl)-1,2,4- Triazole [6], 3-( substituted benzylidene hydrazine)-4-phenyl-5- (p-nitro phenyl-2-yl)-1,2,4-triazole [7] and [8], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl)-2,3-dihydro-1,3-oxazpine-4,7-dione.[9] and [10], 2-(substituted aryl)-3-(p-nitrophenyl)-2-yl-2,3-benzo-1,3-oxazpine-4,7-dione [11] and [12], 2-(substituted aryl) –tetrazolo-1-yl)-[(3-hydrazino-4-phenyl)- 5-p-nitrophenyl)1,2,4-triazole ] [9], 2-substituted aryl-3~-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-thiazolidin-4-one [15] and [16]. 2-(substituted aryl) –3-[3-hydrazino—4-phenyl-5-(p-nitrophenyl)1,2,4-triazole]-2-yl-imidazolidin-4-one [17]and [18] were prepared and the chemical structures of these compounds were characterized by FT-IR , 1H-NMR for some of them Uv/vis spectra , C.H.N analysis ), melting points and the purity was checked. Biological activity of these compounds was evaluated.
Keywords
synthesis; heterocycli; biological activity

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