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The Role of Repaglinide in the Treatment of Secondary Sulphonylureas Failure | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 6, Issue 3, 2009, Pages 441-445 | ||
| Author | ||
| Safaa Ali Khudhair | ||
| Abstract | ||
| Background: About [ 20%-25%] of type 2 diabetes patients are unresponsive to sulphonylureas (primary failure) and an additional 5%-10% of patients each year become unresponsive (secondary failure). Objective: Assessment of the efficacy of repaglinide in the treatment of secondary sulphonylurea failure. Patients and Method: 48 patients with type 2 DM who failed to respond to a combination of full dose of glibenclamide and metformin are put on combination of repaglinide (3mg/day) and metformin and blood glucose is monitored for 9-11 weeks. Results: 12 patients [25%] out of 48 patients with secondary sulphonylureas failure obtained good glycemic control with repaglinide. Conclusion: Repaglinide can induce good glycemic control in some patients with secondary sulphonylureas failure. | ||
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