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Dose-Rsponse Relationship for the Anti-inflammatory Activity of Doxycycline in Experimental Models of Chronic Inflammation | ||
| Medical Journal of Babylon | ||
| Article 1, Volume 6, Issue 3, 2009, Pages 545-550 | ||
| Authors | ||
| Raghdan Z. Al-Saad; Saad A. Hussain; Intesar T. Numan | ||
| Abstract | ||
| Recently, progress has been made to utilize the matrix metalloproteinase inhibitory properties of some drugs for developing anti-inflammatory drugs that are efficacious and relatively free of side effects, and can be used effectively for a long time. The present study was designed to evaluate the dose-response relationship of the anti-inflammatory activity of doxycycline in experimental animal models of chronic inflammation and compared to that produced by the standard drugs dexamethazone and methotrexate. Seventy two rats were allocated into nine groups, each containing 8 rats, for the study of the anti-inflammatory activity of doxycycline in experimental animal model of formaldehyde-induced chronic inflammation; another 16 rats were used, and allocated into two groups, each containing 8 rats, for the study of the anti-inflammatory activity of (doxycycline 2.5 mg/kg) when used in combination with dexamethasone or methotrexate. The result of the present study reported that doxycycline in the dose range of (0.1, 0.2. 0.4, 0.6, 1.2, 2.5 mg/kg) significantly suppress inflammation in experimental animal model of formaldehyde induced chronic inflammation. Combination of doxycycline with dexamethasone (1 mg/kg body weight) significantly suppresses inflammation which was higher than all of the effects produced by other approaches of treatment. In conclusion, doxycycline, in a dose dependent pattern, was effective in attenuating formaldehyde-induced chronic inflammation in rats and has the ability to potentiate the anti-inflammatory activity of dexamethasone and methotrexate | ||
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