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Amelioration Of Doxorubicin Induced Cardiotoxicity | ||
| Al-Qadisiah Medical Journal | ||
| Article 1, Volume 7, Issue 2, 2011, Pages 272-292 PDF (0 K) | ||
| Authors | ||
| Najah R Hadi; Sadiq J Ali; Nadhim Hinti | ||
| Abstract | ||
| The therapeutic usefulness of doxorubicin (DXR), an anthracycline antibiotic, is limited by its cardiotoxicity. The present study investigated the effects of vitamin E, carvedilol, telmisartan and omega-3 against doxorubicin-induced cardiotoxicity in rats using biochemical approaches . Telmisartan (1 mg/kg/day) orally, vitamin E(100 mg/kg) orally. carvedilol (10mg/kg) orally and omega-3 (20 mg/kg) orally were administered orally for 7 days followed by doxorubicin (15 mg/kg) was injected intraperitoneally (ip) as a single dose . Rats treated with DXR showed cardiotoxicity as evidenced by elevation of serum lactate dehydrogenase (LDH) activity, serum creatin kinase (CK-MB);serum malondialdehyde (MDA) level, catalase activity did not change in our study after treatment with doxorubicin . Post-treatment with vitamin E , carvidilol, omega -3 and telmisartan elicited a significant decrease in the activities of LDH and CK-MB in comparison with DXR-treated group. Furthermore , post-treatment with vitamin E , carvidilol, and telmisartan also significantly decreased lipid peroxidation (MDA level) in comparison with DXR group. These results suggest that vitamin E , carvidilol, omega -3 and telmisartan treatment provides a significant protective effect against acute-doxorubicin induced cardiotoxicity in rat. | ||
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