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Study of Cholinesterase Activity in Adult Ewes Treated by the Anthelmintic Drug Levamisole | ||
| Rafidain Journal of Science | ||
| Article 7, Volume 21, Issue 5, 2010, Pages 93-102 PDF (0 K) | ||
| DOI: 10.33899/rjs.2010.37028 | ||
| Authors | ||
| Yaser A. Esmaial; Mohammad H. Ali; Masod H. Megdad; Ashraf S. Alias | ||
| Abstract | ||
| The aim of this study was to examine the toxic effects of levamisole in adult ewes, using a modified electrometric method to measure the cholinesterase ( ChE ) activity in whole blood, plasma and erythrocyte. The normal mean ChE activity (Δ pH / 30 min) was the highest in the erythrocyte (0.64) , followed by the whole blood (0.36) and then in plasma (0.08). In Vitro, levamisole at concentrations (0,25,50,100,200,300) μm/L caused significant inhibition of erythrocyte ChE by (0%, 13%, 15%, 19%, 36% and 54%) respectively. Adult ewes were divided into three groups each group contained 40 animal. The animals were treated with levamisole by doses of (0, 7.5, 15mg/Kg B.W ) by mouth and after zero ( 1,2,3)h blood sample(erythrocyte) was drawn to measure cholinesterase (ChE) activity. The activity was significantly decrease (%19.4) compared to the control. in activity of cholinesterase in the group that was treated by levamisole 15 mg/kg B.W and these results indicate the ability of levamisole to inhibit ChE activity. | ||
| Keywords | ||
| Cholinesterase; Ewe; Electrometric method; levamisole | ||
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