- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Spectrophotometric Determination of Metoclopramide Hydrochloride in Pharmaceutical Preparations Via Oxidative Coupling Reaction | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 16, Issue 4, 2011, Pages 89-95 | ||
| Author | ||
| Nabeel S. Othman | ||
| Abstract | ||
| A simple and rapid spectropotometric method for the determination of metoclopramide-HCl(MCP) was described. The method is based on the oxidative coupling reaction of pyrocatecol (PC) with MCP using ammonium ceric sulphate (ACS) as oxidizing agent in acidic medium to form a water soluble product, that is stable and has a maximum absorption at 500 nm. Beer’s law is obeyed in a concentration range of 5-35 g.ml-1 MCP with a molar absorptivity of 3.01103 l.mol-1.cm-1, a relative error of –0.22 to -0.90 % and a relative standard deviation of 0.09 to 1.90 % depending on the concentration of MCP. The proposed method has been successfully applied to the determination of MCP in various pharmaceutical preparations. | ||
|
Statistics Article View: 78 PDF Download: 45 |
||