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Modefied Method For Synthesis and Charecterization of Aza- Ascorbic Acid | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 16, Issue 4, 2011, Pages 128-135 | ||
| Author | ||
| Mohammad J. Abd AlGhani | ||
| Abstract | ||
| A process was carried out to synthesize Aza-ascorbic acid using ascorbic acid as a starting material. It is based on closing sites (5, 6 ) then acetylation of sites ( 2, 3) to protect the gropes on these positions from side reactions. The produced compound, after acetylation, was treated with (ammonia- methanol) solution to give the substituted amide of ascorbic acid. The hydroxyl group on position (4 ) was converted to benzene sulphonate which is characterized as a good leaving group. Using a good neucleophilic agent will give a chance for amino group in amide derivative of ascorbic acid to attack the sulphonate group on position 4 to produce the aza-ascorbic acid. This method can be considered as alternative to the classical methods which are based on oxidation of the hydroxyl group at position (4) converting it to ketone group followed by cyclization of the amide derivative which is finally reduced by sodium borohydride. The synthesized product was identified by UV and IR spectra. | ||
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