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Spectrophotometric Determination of Mesalazine Via Oxidative Coupling Reaction | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 16, Issue 4, 2011, Pages 64-69 | ||
| Author | ||
| Intisar Adil Shihab | ||
| Abstract | ||
| A simple, rapid and sensitive new spectrophotometric method for the determination of mesalazine .The method is based on the oxidative coupling reaction of mesalazine in acidic medium with pyrocatechol in the presence of potassium chromate as oxidizing agent forming an intense stable purple–red water soluble dye, which exhibits maximum absorption at 530nm. The molar absorptivities ranged from 3685l.mol-1.cm-1 for mesalazine. Beer's law was obeyed over the range of (0.4-10) ppm.The proposed method is applied for the determination of mesalazine in pharmaceutical preparations. | ||
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