Study the genotoxic effect of vitamin A on sperm formation in                  white rat Rattus norvegicus

R. Khalaf, Omar

	Study the genotoxic effect of vitamin A on sperm formation in white rat Rattus norvegicus
Tikrit Journal of Pure Science
Article 1, Volume 16, Issue 3, 2011, Pages 18-23
Author
Omar R. Khalaf
Abstract
Twelve male of the white rats Rattus norvegicus are used in our present study, and divided to four groups. Each group is contained three males. Three groups injected concentrations from vitamin A differences and fourth group by control material above in the membrane for twenty-four days and by seventy-two hours. Animals were killed after twenty- five days of injection, and an autopsy was extracted sperm from its epididymis in accordance with method of ( Wyrobek & Bruce) [23] . Results of our present study showed that males injection of laboratory rats by vitamin A leads to the appearance of sperm abnormalities in hooks represented the loss of the head , spherical of head , and elliptical tail in two concentrations (90&45 mg/kg) in comparison with the control group and at the level of significance (p<0.01) . As well as, statistical analysis showed no significant differences between the group rats injected by vitamin A concentration (25 mg/kg) in comparison with the control group. But in the case of mutilation of losing hooks head, were more influent when compared with the control group and at level of significance (p<0.05) . As well as absence of significant differences between rats injected with vitamin A concentration (25 mg/kg) for the type of deformation elliptical tail in comparison with the control group.

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