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Effect of isolated proteinous compounds from the basidia fruit of the fungus Agaricus campestris in alloxan – induced male diabetic mice | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 15, Issue 2, 2010, Pages 276-284 | ||
| Author | ||
| Eman Saeed Shamoon AL-Choka | ||
| Abstract | ||
| The study included preparing a cold aqueous extract of Mushroom fruit Gel filtration technique were used for the isolation of proteinous precipitate in to compounds and the determination of their molecular weight approximately. Also were studied the effect of cold crud aqueous extract , non proteious extract ,proteinous precipitate, and their compounds Aand B which were isolated from it on haveing hypoglycemic, hypolipidemic, and anti-oxidant properties for alloxan –induced diabetic mice.two compounds (A and B) were isolated from the proteinous precipitate using gel filtration technique and their approximate molecular weight were for A(193152) and for B were (2266) Dalton respectively.. The results were indicated After one week of treatment intraperitoneally of diabetic mice with the cold crud aqueous, non proteinous extracts, proteinous precipitate and protenious compounds (A)and (B) asignificant decrease in the level of blood serum glucose, of malondialdehyde in liver and kidneys tissues, whereas significant increase in the level of high density lipoproteins – cholesterol in blood serum and the level of glutathione of liver and kidneys tissues of alloxan – induced diabetic male mice. From these results conclude that some extracts of Mushroom fruits have anti-diabetic and antioxidant effect in alloxan- induced diabetic mice . | ||
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