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Effect of isolated basic amino acids fraction from Lens Culinaris in normal and experimental diabetic male mice | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 15, Issue 2, 2010, Pages 285-291 | ||
| Author | ||
| Nashwan Ibraheem Abo Al-leheebi | ||
| Abstract | ||
| This study was included to prepare a basic extract contain basic amino acids fraction(baaf) of Lens Culinaris seeds by using ion exchange chromatography from non proteinaceous supernatant , concentration of basic amino acids was determined in isolated basic extract that analyzed by high performance liquid chromatography technique, the project contained the effect of basic extract in levels of glucose, total lipids(T.L), total cholesterol(T.C), triglyceride(T.G), high and very low density lipoprotein cholesterol (HDL-C),(VLDL-C) in blood serum also glutathione(GSH) and malondialdehyde (MDA) levels in liver, kidney, and heart tissues in normal and alloxane diabetic mice After(16) days from treatment with (125)mg/kg body weight (baaf), the results indicated to significant decrease(p<0.05)in glucose , T.Cho, T.G, VLDL-C in blood serum and MDA in liver and heart tissues ,in which it lead to significant increase(p<0.05) in HDL-C level in serum , and glutathione level in liver and kidney alloxane diabetic mice . With a significant decreased(p<0.05)in T.C, T.G, HDL-C and VLDL-C levels in blood serum and GSH in kidney , MDA levels in liver, kidney and heart in tissues, while basic extraction brought about significant increase(p<0.05) in glutathione in liver, heart levels in normal mice. Finally; we propose that the basic fraction may be contribute in treatment patients with diabetes. | ||
| Keywords | ||
| Lentil seeds; diabetes mellitus; Basic amino acids | ||
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