- All Journals
- Al-Qadisiyah University
- Basrah University
- Kirkuk University
- Mosul University
- The Iraqi Borad for Medical Specialization
- University of Anbar
- University of Technology
- Al Mustafa University
- Al-Zahraa University for Women
- Alnoor University
- Kunooz University
- Misan University
- Ninevah University
- Tikrit University
- University of Al-Hamdaniya
- University of Kerbala
Histological and Biochemical Liver Changes in Cholelithasis | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 15, Issue 2, 2010, Pages 5-10 | ||
| Author | ||
| Hamid H. Sarhan | ||
| Abstract | ||
| A prospective study designed to investigate the histopathological changes in livers of 67 patients undergoing cholecystectomy and to relate these changes to the underlying biliary tract pathology.Sixty three had gall stones, one cholesterolosis only, and there were three cases of acute acalaculous cholecystitis. Only 34% of the patients had completely normally liver biopsy specimens. The most clinically important pathology was found in 11 of the 14 patients with choledocholithiasis: three of these had cholangitis and eight had features of large bile duct obstruction (four also had chronic cholestasis and portal-portal linking fibrosis). Non-specific reactive hepatitis was the most common abnormality in remaining 53 patients with cholecystitis alone, and was found in 18. A further four patients had chronic cholestasis without fibrosis was a coincidental finding in another. Clinical symptoms were poorly correlated with gall bladder and liver pathology apart from an association between jaundice and choledocholithiasis. Liver function tests of obstructive pattern were noted in 23 of 58 patients ,most of whom had choledocholithiasis or non-specific reactive hepatitis .Bile cultures were positive in 10 of 42 patients predomininantly in cases of cholangitis and acute cholecystitis. Cholangitis and extensive fibrosis associated with large bile duct obstruction are common findings in patients with choledocholithasis. The liver disease may progress to secondary biliary cirrhosis if the obstruction is not relieved, emphasizing the need for early surgery. A preoperative liver biopsy may be useful to exclude cirrhosis in these patients, but is unlikely to be informative in those with cholecystitis alone. | ||
| Keywords | ||
| gall stones; cholecystectomy; liver changes | ||
|
Statistics Article View: 91 PDF Download: 45 |
||