Abdul Sattar, R., Al-Abachi, M. (2012). Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol. , 3(3), 6-12. doi: 10.37652/juaps.2009.37781
Raghad.S Abdul Sattar; Mouayed Q Al-Abachi. "Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol". , 3, 3, 2012, 6-12. doi: 10.37652/juaps.2009.37781
Abdul Sattar, R., Al-Abachi, M. (2012). 'Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol', , 3(3), pp. 6-12. doi: 10.37652/juaps.2009.37781
Abdul Sattar, R., Al-Abachi, M. Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol. , 2012; 3(3): 6-12. doi: 10.37652/juaps.2009.37781

Spectrophotometric Determination of Nitrazepam in Pharmaceutical Tablets by Oxidative Coupling Reaction with Pyrocatechol

Journal of University of Anbar for Pure Science
Article 3, Volume 3, Issue 3, 2009, Pages 6-12    PDF (383.88 K)
Document Type: Research Paper
DOI: 10.37652/juaps.2009.37781
Authors
Raghad.S Abdul Sattar; Mouayed Q Al-Abachi
University of Baghdad- College of Science
Abstract
A simple and sensitive spectrophotometric method was developed for the determination of nitrazepam
(NZP) in pharmaceutical tablets. The method was based on oxidative coupling organic reaction of reduced NZP with
pyrocatechol in the presence of ferric sulfate to form red water soluble product with maximum absorbance at 510 nm.
The reaction conditions were studied and optimized. The linear range for the determination of NZP, and the detection
limit were 1 – 24 ىg mL-1 and 0.698 ىg mL-1, respectively. The proposed method has been applied
successfully for the determination of NZP in pharmaceutical tablets. A statistical comparison of these results with
those obtained by the British pharmacopoeia procedure using the Student t-test and variance ratio F-test shows a good
agreement and indicates no significant difference in accuracy and precision at the 95% confidence.
Keywords
nitrazepam; Spectrophotometric; Pyrocatechol; Pharmaceutical Tablets
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