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The Role of Cabergoline in Creating Micronucleus and Sperm Headed Abnormality in Male Albino Mouse | ||
| Magazine of Al-Kufa University for Biology | ||
| Article 1, Volume 3, Issue 2, 2011, Pages 8-15 | ||
| Abstract | ||
| The present study was designed to stand on genetic effects important of cabergoline by some laboratory investigations in male albino mice include the micronucleus test and sperm headed abnormality assay. The animals were treated with two oral doses of drug (0.003 and 0.01 mg/kg) given by gavaga for 4 weeks and twice weekly. The result appeared a slight increase in ratio of micronucleus to (0.02) ml/kg in the first dose (0.003 ml/kg) compare with the negative control (0.01 ml/kg), but this increase was not significantly, also the ratio of micronucleus was increase in (0.01 ml/kg ) to (0.03 ml/ kg) and there is no significantly compare with the negative control. On the other hand the results showed a slight increase in ratio of sperm headed abnormality to (3.7 and 3.9 ml/kg) when receiving (0.003 and 0.01 ml/kg) respectively compare with negative control (3.6 ml/kg) but this increase was not significantly. | ||
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