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Determination the Erythrocyte glutathione peroxidase activity and Serum selenium level in patients with breast cancer | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 16, Issue 2, 2011, Pages 4-8 | ||
| Author | ||
| Basma Talib Jasim | ||
| Abstract | ||
| Selenium is a key component of a number of functional selenoproteins required for normal health. The best known of these are the antioxidant glutathione peroxidase enzymes, which remove hydrogen peroxide and damaging lipid and phospholipids hydro peroxides generated in vivo by free radicals and other oxygen derived species. Antioxidant has been suggested to play a role in some physiological conditions and in many disease processes, including carcinogenesis. The aim of the study was to investigate the erythrocyte glutathione peroxidase (GSH-Px) and serum selenium level in patients with breast cancer. The study included thirty female breast cancer patients and twenty normal healthy individuals of age- and sex match who served as controls. In all investigated breast cancer patients significantly lower serum (Se) level, and significantly higher (GSH-Px) activities were found, as compared with the values of healthy controls. Results from this prospective study suggest the increased of erythrocyte(GSH-Px) activity may be a result of a protective mechanism that develops in breast cancer patients against free radical damage, and low serum Se levels is associated with increased breast cancer risk. | ||
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