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Estimation of some T-helper 2 cytokines (IL-4 and IL-10) in HBV Infected Patients and Individuals Vaccinated with Recombinant HB Vaccine | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 16, Issue 1, 2011, Pages 5-9 | ||
| Author | ||
| Hiwa Abdul -Rahman Ahmed | ||
| Abstract | ||
| infection, interleukin-4 (IL-4) and IL-10 are considered examples on T-helper 2 (Th2) cytokines which required for host antiviral immune response and involved in humeral immunity against HBV infection. This study was designed to estimation Th2 cytokines (IL-4 and IL-10) in HBV infected patients and individuals vaccinated with recombinant HB vaccine. Study groups were classified into patient group 35(15 acute (AH) and 20 chronic (CH)), 35 vaccinated group (20 responder (RD) and 15 Non-responder (NRD)) and 18 healthy control (HC) during May to November 2007. Blood samples were taken from patients and hospitals staffs to detection HBsAg, Anti-HBc Ab(IgM), Anti-HBs Ab, IL-4 level and IL-10 level in serum by enzyme linked immunosorbent assay (ELISA) test. The concentration of IL-4 and IL-10 levels in the AH group differed significantly compared with HC and CH patients (p<0.01) by F-test. LSD-analysis for IL-4 revealed same result only between HC and CH (P<0.008). Comparison between CH and both HC and AH, respectively revealed significant differences in IL-10 level (P<0.008) and (P<0.03) by LSD-test. F-test for IL-4 revealed non significant result (P>0.05) among RD, NRD and HN control in ≥30 and <30 years old, respectively, but inverse result was observed in IL-10 levels (p<0.05). LSD-test revealed (P>0.05) between all study group regarding IL-4, however the level of IL-10 were (P<0.014) and (P<0.01) in RD and NR groups among ≥30 and <30 years old, respectively. Indeed (P<0.03) between RD and HN groups in age <30 years. Conclusion: In this study significant elevation of IL-4 and IL-10 levels was observed in AH patients compared with CH patients and healthy control. Same result was seen in IL-10 among RD and NRD in ≥30 and <30 years old, as well as between RD and HN groups in age <30 years | ||
| Keywords | ||
| HBV; recombinant HB vaccine | ||
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