Effect of fruits of chinaberry on rats fertility and histological structure of female reproductive system

Hamad Jandari Jumaa, Dr.

	Effect of fruits of chinaberry on rats fertility and histological structure of female reproductive system
Tikrit Journal of Pure Science
Article 1, Volume 14, Issue 1, 2009, Pages 207-214
Author
Dr. Hamad Jandari Jumaa
Abstract
The present study was conducted on adult rats Rattus norvegicus from both sexes whose body weight ranged between (200-350) gm. The results indicates that animals which were given crushed of fresh mature fruit of Melia azedarach L. a dose of 25 g/kg of body weight for five weeks showed clinical signs including loss of appetite, lassitude, allergic symptoms in face and weakness. While animals which were given dose rate of 50 g./kg. B.W. showed allergy around eyes and hair fell down in the same region, nervous excitation, polyurea. Doses of (25 , 50 g/kg. B.W.) daily for five weeks caused infertility effect in treated male and female rats and there was a 100 % reduction in fertility, while in contral group the fertility percentage was 40 %. The infertility in the dose (50 g/kg) was associated with loss of libido and impotence. Sections taken from adult female rats treated with dose of 25 and 50 g/kg B.W. revealed happening hyperplasia of surface endothelium of oviduct, congestion of blood vessels of ovarian tissue, fibrosis of the wall of oviducts failure of ovarian follicles to reach maturity, necrosis and exfoliation of endometrium

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