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Study of Some Antioxidants in Brain Tumor Patients | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 14, Issue 1, 2009, Pages 91-96 | ||
| Author | ||
| Kusay A. Al-Chalabi | ||
| Abstract | ||
| Oxidative stress may be a key feature, and hence important determinant of blood serum of brain tumor patients. To investigate this, we determined some antioxidants status [albumin, uric acid, glutathione, ceruloplasmin, nitric oxide, and superoxide dismutase activity (SOD) and lipid peroxidation status {malondialdehyde (MDA}] in a blood serum of (31) patients with different types of brain tumor. A follow-up study was done with (25) post operative patients. On comparison with blood serum from normal individuals, albumin was significantly decrease while uric acid, nitric oxide and malondialdehyde were significantly increase. Glutathione and superoxide dismutase were decreased, but the decrease was statistically insignificant. Ceruloplasmin levels remained in the normal range. In a comparative study of pre operative and post operative cases, serum albumin and malondialdehyde levels in post operative brain tumor patients were significantly increase, while the uric acid was significantly decrease than those in the pre operative state. There was no significantly difference in the serum level of glutathione, ceruloplasmin, nitric oxide and in the activity of (SOD). The conclusion of the present study showed that the brain tumor patients which have a compromised antioxidant status before surgery and it remains poor for one month following the operation. | ||
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