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Synthesis and study of antibacterial activity of some new bis 1,3,4-oxadiazole derivatives | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 14, Issue 1, 2009, Pages 102-107 | ||
| Author | ||
| Gazwan H.A. Al-Somaidaie | ||
| Abstract | ||
| Some of succinic acid hydrazone derivatives were prepared from the reaction of succinic acid hydrazide(3) with different benzaldehydes, then cyclization of hydrazones (4a-e) in glacial acetic acid and lead dioxide resulted into the formation of new bis-1,3,4-oxadiazole derivatives (5a-e). The reactions were followed by TLC and the synthesized compounds were confirmed by their IR and U.V. spectra. The antibacterial activity of the synthesized compounds against the four bacterial species was also studied. | ||
| Keywords | ||
| Hydrazone; oxadiazole; antibacterial activity | ||
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