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Histological Changes Of Mice Skin Infected by Nocardia asteroides (Bacteria Isolated From The Soil) | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 14, Issue 1, 2009, Pages 37-41 | ||
| Author | ||
| Ramzia Hassan Abdul Rahman | ||
| Abstract | ||
| Experimental infection in laboratory Mice of (18-20) gm weight and (4-8) weeks age was made by injection bacterial solution containing Nocardia asteroides isolated from the soil in concentration of (1×107) CFU/ml, in the foot pads of these animals. The results proved the ability of these bacteria to cause infection after about 30 days of inoculation and resulted in many histological changes in the sole of the foot of these mice represented by inflammatory cells infiltration and abscess formation containing many granules can be seen by the naked eye represent the Nocardia asteroides bacteria whichare thread like, positive for gram stain and can be stain by Modified Ziehl-Neelsen. This study proved that those mice inoculated by Nocardia asteroides suspension by injection in their sole lead to infection and many histological changes in the foot skin were obvious. Bacterial clearance or disease progression is related to pathogenic or virulence factors of the bacteria in the one hand and the immune response killing ability of host in the other hand | ||
| Keywords | ||
| Nocardia asteroides; Nocardia asteroides in soil; cutaneous Nocardiosis; superficial skin infection | ||
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