The effect of passive smoking and alcohol on the embryonic development and histological structure of the eye and initiation malformations in the Swiss mouse embryo

Malallah Hamodi, Hani

	The effect of passive smoking and alcohol on the embryonic development and histological structure of the eye and initiation malformations in the Swiss mouse embryo
Tikrit Journal of Pure Science
Article 1, Volume 13, Issue 1, 2008, Pages 96-106
Author
Hani Malallah Hamodi
Abstract
The present study aims at investigating the effects of both passive smoking and ethyl alcohol to induce embryonic malformations during the embryogical eye development of the Swiss albino mice Mus musculus. The pregnant females were exposed to cigrate smoking are variable time periods (1.5, 2 , 2.5, 3) hours daily, With respect to ethyl alcohol. The dose was given orally with gradual concentrations (15% , 20% ,25%, 30%) daily. All the experiments above started at the 7th day of pregnancy until delivery of neonate. The results revealed that both passive smoking and ethyl alcohol have no effects on prolongation of the period of pregnancy of the albino mice, compared with the control group. On the other hand, at (1.5) hrs exposure to passive smoking and (15%) conc. of ethyl alcohol, no morphological lesions were observed, while the histological lesions were the retinal duplication, adhering of lens and cornea and choroids Oedema. While at (2) hrs of smoking exposure and (20%) alcohol concentration, the ratio of malformed embryos reached to(40%). The most distinct lesions were cranial deformity, deviation of eye and external ear from the true sites. Additionally, the lens cataract appeared at (2.5) hrs of smoking exposure and (25%) of alcoholic concentration the ratio of malformed embryos were (58%). The injuries were represented in incomplete brain growth, the reduction of vitreous chamber and eye duplication for the first time. While at (3) hrs smoking exposure and (30%) alcoholic concentration, the malformed embryos ratio reached to(100%). The deformities represented in complete cleft of palate, skeletal malformation, eye atrophy with coagulated necrosis of retinal cells soma, compared with the control group

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