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Histopathological effect of ethinylestradiol on lung of albino rats (Ratus narwegecus) | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 13, Issue 2, 2008, Pages 36-39 | ||
| Author | ||
| Treefa Farouq Ismail | ||
| Abstract | ||
| The present study was performed to investigate the histological lesions caused by ethinylestradiol, on albino rats lung. Three doses of ethinylestradiol were used 1, 2 and 3 mg/kg b.w./day for 4 weeks, the study were conducted on 20 rats divided into 4 groups, 3 groups were experimentally adminstrate orally ethinylestradiol and the last group was the control. After that the animals were killed by exsanguinations under chloroform anesthesia, and the lungs were fixed for histopathological studies. Histological changes were observed in the lung manifested by focal attelactasis (failar of the lungs to expand fully), emphysema(the alveolar walls are a tropic and thin in places they have broken down to form spaces considerable larger than normal alveoli), congestion (accumulation of erythrocytes between the alveolar cells). Lymphatic infiltration(accumulation of large number of white blood cells between and inside alveolar sac), also showed accumulation of large number of lymphocytes around the bronchiole (peri-bronchial lymphocyte infiltration), Edema (accumulation of fluid), hemorrhage and hyperplasia smooth muscle in wall of pulmonary blood vessels. | ||
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