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Spectrophotometric method for Assay of Salbutamol in Pharmaceutical Formulations | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 13, Issue 2, 2008, Pages 90-95 | ||
| Author | ||
| Mohammed S. Al-Enizzi | ||
| Abstract | ||
| A simple and sensitive spectrophotometric method is proposed for the determination of salbutamol. The method based on coupling of 4-aminoantipyrine (4-AAP) with salbutamol to give a new ligand that reacts with copperII to give intensely red colored chelate at 60°C. The colored product is quantified spectrophotometrically at 500nm. The optimization of the experimental conditions is described. The method has been used for the determination of 0.5–30.0 μgml−1 salbutamol. The accuracy of the method is achieved by the values of recovery (100 ± 0.05%) and the precision is supported by relative standard deviation (1.67%) values. The sensitivity of the method is indicated by molar absorptivity of 10106 l.mol-1.cm-1. The results of the method is compared with the official method. The interference of common drug additives was also studied. The proposed method is applied successfully to the determination of salbutamol in pharmaceutical preparations. | ||
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