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Cytoplasmic expression of matrixmetalloproteinases (MMP-2,MMP-9) in transitional cell carcinomaof the urinary bladder | ||
| Baghdad Science Journal | ||
| Article 1, Volume 8, Issue 1, 2011, Pages 440-446 | ||
| Authors | ||
| Kalid T. AL-Naib; Ghanema S. Mohammed; May K. Ismail | ||
| Abstract | ||
| This study was designed by using 36 paraffin embedded tumor tissues obtained from TCC patients , 27 patients were males and 9 were females with male to female ratio of 3:1 . the mean patients age was 60 years (range between 35 and 97 years ) . According to the histopathological reports; malignant tissues were classified in to grades( І, І І, І І І) each one consist of 12 biopsies; and stages (Ta,T1,T2) each one consist of (3,25,8) biopsies respectively. 10 normal bladder tissues (autopsies) obtained from forensic medicine institute of 6 males and 4 females their age ranged between 36 and 65 years . All specimens undergone to Immunohistochemistry technique to investigate the cytoplasmic expression of MMP-2, MMP-9 which showed a significant increase in malignant tissues compaired with the normal tissues (P<0.05). According to the histopathological criteria of malignant tissues ; MMP-2 and MMP-9 showed a positive relation with tumor grade progression ; so cytoplasmic expression of there enzymes was increased with tumor grade increase (p<0.05) , (p<0.05) respectively From this study we conclude that overexpression of MMP-2 , MMP-9 are correlated with TCC invasion and progression . | ||
| Keywords | ||
| MMP | ||
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