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Effect of ethinylestradiol on testis of albino rats (Ratus narwegecus) | ||
| Tikrit Journal of Pure Science | ||
| Article 1, Volume 12, Issue 1, 2007, Pages 226-229 | ||
| Author | ||
| Treefa Farouq Ismail | ||
| Abstract | ||
| The present study was conducted to clarify the histological effect of ethinylestradiol, on albino rat testis. The albino rats were administrated three oral dose of ethinylestradiol 1,2and3 mg/kg b.w./day for 4 weeks. After that the testis were fixed for histological studies. Histological changes were observed in the testis, manifested by (degenerative changes in spermatogenesis, disruption in normal epithelial organization, decreased number of elongated sperm, depletion in germinal layer, dilatation of interstitial space ,existing vacuoles in certain regions of interstitial spaces and present of giant multinucleated cell. Also results indicated that ethinylestradiol has affected on the body and testis weight. We attribute the testis toxicity during ethinylestradiol exposure to the suppression of testicular testosterone levels. | ||
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