Effect of thyme plant in level glutathione , lipid peroxide and some parameters in local male rabbits and treated with hydrogen peroxide

M. AL, Muntaha; Kattan,

	Effect of thyme plant in level glutathione , lipid peroxide and some parameters in local male rabbits and treated with hydrogen peroxide
Tikrit Journal of Pure Science
Article 1, Volume 12, Issue 1, 2007, Pages 146-151
Authors
Muntaha M. AL;
Abstract
This study was conducted to investigate the effect of thyme plant to determined its ability in preventing oxidative stress of hydrogen peroxide (0.5 %) consumed in drinking water in local male rabbits (7 – 8) months old. Rabbits were divided into 4 group (4 rabbits of each). Thyme was used as capsules arally (1000 mg / kg. B. wt). The rabbits were treated dialy for four weeks . Oxidative stress was determined through measuring the levels of Glutathione(GSH) and Malondialdehyde (MDA) in liver tissue and of Alanine aminotransferase( ALT) and Aspartate aminotransferase (AST) enzymes levels. H2O2 (0.5%) treated showed significant decrease in liver tissue GSH and a significant increase in liver tissue MDA, the levels of serum ALT and AST were significantly increase also the above changes indicate the ability of H2O2 (0.5%) in the induction of oxidative stress in local male rabbits. as well as the appearance pathological changes in some organs as lung with some treatment with H2o2. Histological examination showed lipid changes of necrosis with vaceulation in the cytoplasm of hepayic cells. The treatment with thyme plant showed the following results significant decrease in Alanine aminotransferase and Aspartate aminotransferase, also significant decrease in liver tissue MDA and significant increase in GSH level , significant decrease in liver fat % .

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