Thyroid Auto-antibodies in Goitrous Euthyroid Patients in Iraq

Ibrahim AL-Lehibi, Khalid

	Thyroid Auto-antibodies in Goitrous Euthyroid Patients in Iraq
Tikrit Journal of Pure Science
Article 1, Volume 12, Issue 1, 2007, Pages 90-95
Author
Khalid Ibrahim AL-Lehibi
Abstract
Thyroid auto-antibodies, especially anti-thyroglobulin antibodies (TgAb) and anti-thyroperoxidase antibodies (TPO) are present in positive titers in over 90% of auto-immune thyroiditis, but they are also present in positive titers in about 10-20% of the general population and females outnumber males. Among the 112 patients with goiter, 99 were females (88.39%) and 13 were males (11.60%), with most of patients fall in the age range of 26-46years (60.68%). Fine needle aspiration biopsy (F.N.A.) which was performed on 39 patients showed a colloid goiter in 79.48% of them.. Out of those 112 patients, 42 (37.5%) have a positive thyroid auto-antibody titer, while the other 70 (62.5%) have either a borderline or a negative titer ( p-value< 0.05). Among the positive 42 (37.5%) patients, most of cases (64.2%) fall in the age range between 26-45, with female predominance (90.47% for females and 9.52% for males). Mean titer of anti-thyroglobulin antibodies (anti-TgAb) was 577.88 i.u./mL and that for anti-thyroperoxidase antibodies (anti-TPOAb) was 203.21 i.u./ml ( p-value < 0.001) . Among the normal 80 persons, 70 (87.5%) were females, and 10 (12.5%) were males. The auto-antibody test was positive in 18 persons (22.5%), 17 females and 1 male only. Key words: Anti-thyroglobulin auto-antibodies (TgAb), anti-thyroperoxidase auto-antibodies (TPOAb), auto-immune thyroid disease (AITD).

Statistics Article View: 102 PDF Download: 68